I would love to see this same analysis with a gut probiotic! I am never convinced if I'm wasting my money, which strains are best, should I do refrigerated or shelf-stable, etc.

Anecdata/placebo/whatever: I use BioGaia's Gastrus tablets and they increase my quality of life noticeably, and I can tell when I've been off them for a while. I got refrigerated deliveries of probiotic yoghurt drinks for a while previously and in addition to the faff, didn't notice as good results.

Additional Anecdata: I head about BioGaia's Gastrus tablets here on HN a couple of years ago and they have dramatically improved my wife's quality of life as well. She suffered from significant GI problems. We bought a pack of the BioGaia tablets based on an anecdote here. Within about 3 weeks her year-long GI problems were gone. She discontinued the tablets and the GI issues stayed away. About 18 months later, after a period of heavy stress and travel, her GI issues returned and then disappeared again after another round of BioGaia tablets.

Thank you both for the anecdata!

As far as I am aware, fiber has infinitely superior research behind it with far more drastic effects. Just take fiber if you're worried about gut health imo.

Yes, feeding good bacteria is the best bet. Probiotics are transient, they don’t colonize.

How do they get there initially?

The environment we live in and the foods we eat are hardly sterile.

There is also a significant microbiome on your skin.

I agree, but if one has ever taken an antibiotic then they should replace the bacteria that they lost? Strong antibiotics completely destroy the gut biome

The research doesn't strongly support probiotics even in that case one way or the other.

I haven't logged into Plex in a while but did decide that the next time I need it will just setup Jellyfin instead. Nice to see they support all my devices iOS AndroidTV FireTV

I didn't know what foamcore inserts were until now, bu tthis is useful. I have lots of broken boardgame boxes

Welcome to a whole new obsession!

Same here, its pretty cool!

> Six years later, Hammersmith Bridge remains closed to vehicles. The solution proposed by local authorities costs £250m and has no funding.

If this is not a failure of Mayor of London Sadiq Khan, then who? Where I grew up, new bridges were paid for by tolls until the building cost was paid then taxes covered occasional maintenance.

> Netflix says they’re keeping the company separate

For a while... Eventually, you can expect that functions will be streamlined, compacted, and impacted

TY. That is what I thought this was

Has SpaceX revealed what they plan to do with the Texas Starbase once they start launching Starship from Florda? Will they just stop using it?

They seem to like to iterate. The Falcon 9s flying now are essentially version 5. I can imagine they’ll keep experimenting with Starship designs for a while.

"require more or less the entire world's GDP to be invested in the US for several consecutive years"

Whoever wrote that is making stuff up now, even worse than Sam Altman asking for trillions of dollars to build data centers

https://www.wsj.com/tech/ai/sam-altman-seeks-trillions-of-do...

I agree the article seemed disingenous and almost felt like it was shady (can you believe the EU lets them cancel in a sane way?!). When I hear ARR, I don't think of an annual contract. ARR is equivalent to MRR*12 and can be a mix of contract types or even utility spend ($ per bytes). I understand that "committed spend" is when a business agrees to pay $XX annually, but that's not defined by ARR.

>> ARR is equivalent to MRR12

Sure but if you actually have customers paying the annual fee in one go (instead of 12 monthly payments when they can cancel at anytime) the ARR number will be much more reliable. With MRR12 you're counting people who sign up for a month and quit.

And ARR assumes it's recurring too - it's a metric that (people incorrectly think) shows how good your business is at retaining revenue year-over-year.

If a big proportion of contracts in Y1 get terminated at the end of the 12m period (because, say, the customer forgot to renew) - then the ARR will drop like a rock in Y2.