Joining Google was an eye-opener for me on this. Was the first time I encountered an IT department (TechStop) that didn't act like a police force and instead had your back, helping you get where you needed to be. Was always the first thing I would show guests on a tour of the campus.
TechStop is/was great. But Windows users had locked down workstations where IT whitelisted binaries. I assume the approval process sucked about as much as normal.
Many Google employees use desktop Linux which is basically unheard of outside the tech world. That by itself simplifies things quite a bit. Not many people writing viruses posing as screensavers for Google's in house Linux strain. Anyone who cracks that is probably an APT attacker and those require different approaches.