I've been working on a quite simplistic tool which currently just supports writing out DXFs and moving tools in lines and arcs for a 3D preview in OpenPythonSCAD --- I _think_ I can envision what you are describing, and it sounds very interesting, and might be an approach I'd want to look into for 4th and 5th axis work --- do you have any texts/references which you could share/point to?
In general, GA and its variants like PGA are good at calculating tangents and offsets for points, lines, planes, spheres, and other parametric surfaces. The key benefit is that the exact same algorithm will work in 2D, 3D, 4D, or any higher number of dimensions. This could in principle allow very elegant formulas for tasks such as "find the biggest thing that won't hit this other thing at any point in time" or the same thing but with a 0.1 mm gap. Similarly, it's possible to reuse the same code and "human intuition" in very high dimensional spaces, such phase space used in more complex motion planning or engineering simulation scenarios.
I actually have that book in my "to be read" pile, underneath some math texts which I believe will make it accessible to me --- will have to get to studying....
