My use-cases for server-side WASM Python are described here: https://simonwillison.net/2026/Jun/6/micropython-in-a-sandbo... - basically I want to offer end-user customization features that run custom code without buggy or malicious code crashing my app or leaking their data.
Running arbitrary untrusted code safely is pretty easy nowadays, so long as the code is written in Javascript and you want to run it in a browser. It's only a little harder if the code is written in another language but targets WASM and browser APIs, or if you want to run your WASM inside of NodeJS, and there's even good support for running Python in a browser or Node.
Once you get away from running in a JS environment or away from code that's written with the intention of running in a WASM sandbox, if you don't want to have to modify the code for your environment then you're going to start having problems. This looks like a good step for anyone wanting to run arbitrary Python outside of a browser environment.
Fair -- but I was more meaning that when I browse an arbitrary untrusted website I almost always allow the site owner to run arbitrary untrusted code on my machine. They might not send me any JS, but if they do then my browser will happily execute it.
I was thinking the client side WASM version would be useful as a platform for beginners to practice a subset of Python in.
I can't really think of any good WASI use cases.