I'm currently using Fluxxor[1] which reifies the Flux architecture with Stores and a central dispatcher. I did some research into Backbone.Model bindings but eventually decided to go "full Flux". I've yet to regret my decision even though my app has grown quite complex.

The best part is, thanks to React & Flux I'm building a large scale web app without jQuery for the first time in my life :)

[1] http://fluxxor.com/